Drug delivery to the brain : physiological concepts, methodologies and approaches /

Drug delivery to the brain : physiological concepts, methodologies and approaches /

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Bibliographic Details
Imprint:	New York : Springer Science+Business Media, 2013.
Description:	1 online resource (737 pages) : illustrations.
Language:	English
Series:	AAPS advances in the pharmaceutical sciences series ; 10 AAPS advances in the pharmaceutical sciences series ; v. 10.
Subject:	Drug delivery systems. Absorption (Physiology) Absorption (Physiology) Drug delivery systems. Central Nervous System Agents -- pharmacokinetics. Blood-Brain Barrier -- physiology. Brain -- metabolism. Drug Delivery Systems -- methods. Drug Design.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/11082706

Hidden Bibliographic Details
Other authors / contributors:	Hammarlund-Udenaes, Margareta. Lange, Elizabeth C. M. de Thorne, Robert G.
ISBN:	9781461491057 1461491053 1461491045 9781461491040 9781461491040
Digital file characteristics:	text file PDF
Notes:	Includes bibliographical references and index. Online resource; title from PDF title page (ebrary, viewed January 2, 2014).
Summary:	The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood -brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma.
Other form:	Print version: Drug delivery to the brain. New York : Springer Science+Business Media, 2013 9781461491040 1461491045
Standard no.:	10.1007/978-1-4614-9105-7

Table of Contents:

Part I. Physiology and basic principles for drug handling by the brain
Part II. Pharmacokinetic concepts in brain drug delivery
Part III. Industrial approaches for investigation of potential central nervous system drugs
Part IV. Strategies for improved central nervous system drug delivery
Part V. Brain drug delivery in disease conditions.