Hidden Bibliographic Details
| Other authors / contributors: | Wang, Sheng, author.
Ma, Jianzhu, author.
|
|---|
| ISBN: | 9783319149141
3319149148
331914913X
9783319149134
9783319149134
|
|---|
| Notes: | Includes bibliographical references.
Online resource; title from PDF title page (SpringerLink, viewed February 4, 2015).
|
|---|
| Summary: | This work covers sequence-based protein homology detection, a fundamental and challenging bioinformatics problem with a variety of real-world applications. The text first surveys a few popular homology detection methods, such as Position-Specific Scoring Matrix (PSSM) and Hidden Markov Model (HMM) based methods, and then describes a novel Markov Random Fields (MRF) based method developed by the authors. MRF-based methods are much more sensitive than HMM- and PSSM-based methods for remote homolog detection and fold recognition, as MRFs can model long-range residue-residue interaction. The text also describes the installation, usage and result interpretation of programs implementing the MRF-based method.
|
|---|
| Other form: | Printed edition: 9783319149134
|
|---|
| Standard no.: | 10.1007/978-3-319-14914-1
|
|---|
