Hidden Bibliographic Details
| Other authors / contributors: | Metcalf, Brian W.
Dillon, Susan, 1952-
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| ISBN: | 9780123693938
0123693934
9780080465975
0080465978
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| Digital file characteristics: | data file
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| Notes: | Includes bibliographical references and index.
Print version record.
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| Summary: | This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.
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| Other form: | Print version: Target validation in drug discovery. Amsterdam ; Boston : Academic Press, ©2007 0123693934 9780123693938
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