Hidden Bibliographic Details
| Other authors / contributors: | Li, Min, 1962-
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| ISBN: | 9781592596836
1592596835
1280831588
9781280831584
9786610831586
6610831580
9781617371462
0896037134
9780896037137
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| Notes: | Includes bibliographical references and index.
English.
Print version record.
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| Summary: | In NMDA Receptor Protocols, Min Li and a panel of hands-on experimentalists detail state-of-the-art molecular techniques for studying NMDA ligand-gated ion channels and developing assays for nontherapeutic lead selection. The topics range from cDNA cloning to in vitro and in vivo investigation of the channel complex in the mammalian brain. Additional topics include the biochemical analysis of the channel protein and the construction of various heterologous systems for both basic research and high throughput screens (HTS) for pharmaceutical chemicals. Although the focus is on NMDA receptors, the methods are applicable to other ligand-gated ion channels and with some modification may be extended to related membrane receptors or signaling receptors. NMDA Receptor Protocols provides today's scientists at all skill levels a diverse collection of highly reproducible molecular techniques for ion channel research and biotherapeutic development. Eminently practical and reproducible, these techniques offer powerful methods for basic research on NMDA receptor structure and function, as well as enormous opportunities for clinical investigation toward the development of novel bioactive compounds.
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| Other form: | Print version: NMDA receptor protocols. Totowa, N.J. : Humana Press, ©1999 0896037134 9780896037137
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| Standard no.: | 10.1385/1592596835.
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