Hidden Bibliographic Details
| Varying Form of Title: | X inactivation and sex differences in disease
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| ISBN: | 9780199720064
0199720061
128116268X
9781281162687
0195188128
9780195188127
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| Digital file characteristics: | data file
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| Notes: | Includes bibliographical references (pages 241-257) and index.
Print version record.
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| Summary: | Women can be described as genetic mosaics because they have two distinctly different types of cells throughout their bodies. Unlike males, who have one X chromosome (inherited from their mother), females have two X chromosomes in every cell (one from each parent). The fathers copy works in some cells, while the mothers copy works in others. These two X chromosomes often function differently, especially if one carries a defective gene. Much has been written about the Y chromosome and its role in inducing maleness. This will be the first book about the X chromosome as a key to female development and the role of X-related factors in the etiology of sex differences in human disease. Barbara Migeon, from the renowned McKusick-Nathan Institute at Johns Hopkins, is a major figure in clinical genetics and is eminently qualified to write this book, and she writes clearly and effectively. She describes both the underlying molecular mechanisms and the remarkable genetic consequences of X inactivation and its role in determining the biological concepts characteristic of women.
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| Other form: | Print version: Migeon, Barbara R. Females are mosaics. Oxford ; New York : Oxford University Press, 2007 0195188128 9780195188127
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