MIF : most interesting factor /

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Bibliographic Details
Imprint:Singapore ; New Jersey : World Scientific, ©2007.
Description:1 online resource
Language:English
Subject:
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11168094
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Other authors / contributors:Bucala, Richard.
ISBN:9812775919
9789812775917
Notes:Includes bibliographical references and index.
Summary:In recent years, researchers have identified a pivotal, upstream role for macrophage migration inhibitory factor (MIF) in the innate immune response. This pioneering book describes this renaissance of knowledge in the biology of MIF. Topics covered include MIF's molecular mechanism of action, its counterregulatory action on the immunosuppressive properties of glucocorticoids, its role in the production of proinflammatory mediators as shown in cell-based and animal studies; and its central role in human inflammation. Human genetic studies have identified allelic forms of the MIF gene, and high-