Piperidine-based drug discovery /

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Bibliographic Details
Author / Creator:Vardanyan, R. S. (Ruben S.)
Imprint:Amsterdam, Netherlands : Elsevier, [2017]
Description:1 online resource : illustrations
Language:English
Series:Heterocyclic drug discovery series
Heterocyclic drug discovery series.
Subject:
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11308307
Hidden Bibliographic Details
ISBN:9780128134283
0128134283
9780128051573
0128051574
Notes:Includes bibliographical references and index.
Online resource; title from PDF title page (EBSCO, viewed June 26, 2017)
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Summary:Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related areas, it is hoped that this volume will encourage and inspire the continued design and development of novel pharmaceuticals based on Piperidine and its derivatives. Heterocyclic compounds are of central importance to medicinal chemistry, as demonstrated by the high percentage of marketable drugs that feature heterocyclic fragments in their structures. As starting points for drug discovery they offer a broad range of attractive properties, and a detailed understanding of the particular characteristics of each is of great benefit to researchers. The most commonly used heterocycle among US FDA approved pharmaceuticals, Piperidine is an extremely important building block in the synthesis of medicinal agents. This heterocycle and its derivatives exhibit a number of important functionalities and have been employed variously as CNS modulators, antiaggregants, anticoagulants, antihistamines, anti-cancer drugs and analgesics.
Other form:Original 0128051574 9780128051573