Stereoselective heterocycle synthesis via alkene difunctionalization : bulky phosphine ligands enable Pd-catalyzed arylhalogenation, arylcynation and diarylation /

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Bibliographic Details
Author / Creator:Petrone, David A., author.
Imprint:Cham, Switzerland : Springer, 2018.
Description:1 online resource
Language:English
Series:Springer theses : recognizing outstanding Ph. D. research
Springer theses.
Subject:
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11654160
Hidden Bibliographic Details
ISBN:9783319775074
3319775073
3319775065
9783319775067
Digital file characteristics:PDF
text file
Notes:Includes bibliographical references.
Online resource; title from PDF title page (EBSCO, viewed April 10, 2018).
Summary:This book investigates the use of palladium modified by bulky ligands as catalysts for new chemical transformations that rapidly assemble several classes of complex heterocyles. It documents the development of new chemical reactions involving carbon-carbon (C-C) and carbon-halogen (C-X) bond formation in the context of alkene difunctionalization and dearomatization reactions. Due to the ubiquity of heterocycles in bioactive natural products and life-improving pharmaceutical treatments, a long-term goal for synthetic organic chemists has been to develop novel and creative heterocycle syntheses that illicit a high degree of product diversity and are characterized by mild reaction conditions and limited waste production. A considerable fraction of leading pharmaceutical drugs contain at least one heterocycle within their chemical structure, and their prevalence in these technologies is strong evidence that the fundamental curiosities of organic chemistry lead to real-world solutions for the health and wellness of the global population.
Other form:Print version: 3319775065 9783319775067
Standard no.:10.1007/978-3-319-77507-4