Reproductive and developmental toxicology /

Saved in:
Bibliographic Details
Edition:Second edition.
Imprint:Saint Louis : Elsevier Science, 2017.
Description:1 online resource (xiii, 1446 pages) : illustrations
Language:English
Subject:
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11736307
Hidden Bibliographic Details
Other authors / contributors:Gupta, Ramesh C. (Ramesh Chandra), 1949- editor.
ISBN:9780128042403
0128042400
0128042397
9780128042397
Notes:Reproductive Senescence.
Includes bibliographical references and index.
Print version record.
Summary:Of the Effects of Estrogens and Progesterone During the Female Reproductive Cycle -- Oocyte/Sperm Transport, Normal Capacitation of Sperm, and Fertilization -- Transport of the Ovulated Oocyte -- Transport and Capacitation of Spermatozoa -- Transport of Spermatozoa -- Capacitation of Spermatozoa -- Fertilization -- Important Aspects of Normal Embryonic and Fetal Development -- Historical Perspective -- Blastocyst Formation and Differentiation of the Germ Cell Layers -- "Maternal Recognition of Pregnancy" and Implantation -- Formation of the Extraembryonic Membranes -- Concepts and Definitions -- Placental Types -- Placental Function -- The "Placental Barrier" -- Sex Determination and Sexual Differentiation of Reproductive Function -- Genotypic Sex and Development of the Primitive Sex Cords -- Gonadal Sex Determination and Phenotypic Sexual Differentiation -- Development of the Male Phenotype -- Development of the Female Phenotype -- Sexual Differentiation of the Brain -- The Endocrinology of Pregnancy -- Gestational Hormones -- Parturition -- Physiology of Parturition -- The Mammary Glands -- Anatomy -- Physiology of Lactation -- Lactogenesis -- Control of Prolactin Secretion -- Reproductive Senescence -- CONCLUDING REMARKS AND FUTURE DIRECTIONS -- References -- 3 - Pharmacokinetics in Pregnancy -- INTRODUCTION -- FACTORS AFFECTING PHARMACOKINETICS IN PREGNANCY -- Absorption -- Distribution -- Metabolism -- Renal Excretion -- THE FETAL COMPARTMENT -- Drug Metabolism Within the Fetal Compartment -- Drug Accumulation Within the Fetal Compartment -- HIGHLIGHTING THE VALUE OF PK INFORMATION IN PREGNANCY: TOCOLYTIC THERAPY -- MATERNAL DISEASE AND OBSTETRICAL COMPLICATIONS -- ORIGINS OF THE KNOWLEDGE GAP -- CURRENT INITIATIVES AND FUTURE DIRECTIONS -- PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING -- CONCLUDING REMARKS AND FUTURE DIRECTIONS.
Other form:Print version: Gupta, Ramesh C. Reproductive and Developmental Toxicology. Saint Louis : Elsevier Science, ©2017 9780128042397