Hidden Bibliographic Details
| Other authors / contributors: | Scott, Mark G. H., editor.
Laporte, Stéphane A., editor.
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| ISBN: | 9781493991587
1493991582
9781493991570
1493991574
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| Notes: | Includes bibliographical references and index.
Online resource; title from PDF title page (SpringerLink, viewed April 3, 2019).
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| Summary: | This volume looks at various approaches to study the pleiotropic roles of b-arrestins (b-arrs) in the control of signal transduction, and the resulting cellular and in vivo consequences that arise. The chapters in this book cover diverse topics around b-arrs such as their established roles in GPCR regulation and trafficking; regulatory scaffolding functions of b-arrs in MAPK signaling, cAMP hydrolysis and cytoskeletal dynamics; proteomic analysis of the b-arr interactome; mathematical modelling of b-arr signaling networks; functional selectivity involving biased ligands; nucleocytoplasmic trafficking and primary cilia-associated functions of b-arrs; conformational plasticity of b-arrs; and the roles of b-arrs in allergic inflammation, Type 2 Diabetes, Parkinson's disease, and cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
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| Other form: | Print version: Beta-arrestins. New York, NY : Humana Press, 2019 1493991574 9781493991570
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| Standard no.: | 10.1007/978-1-4939-9158-7
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