Hidden Bibliographic Details
| Other authors / contributors: | Hesson, Luke B., editor.
Pritchard, Antonia L., editor.
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| ISBN: | 9789811389580
9811389586
9789811389573
9811389578
9789811389597
9811389594
9789811389603
9811389608
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| Digital file characteristics: | text file
PDF
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| Notes: | Online resource; title from PDF title page (SpringerLink, viewed September 18, 2019).
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| Summary: | In genetic pathology, epigenetic testing is rare and under utilised. In this book, we introduce epigenetics to a non-expert scientific audience and describe current and future clinical utility of epigenetic testing. By focussing on epigenetics in human disease this book will guide professionals (scientists and clinicians) to understand how epigenetics is relevant in a clinical context, and to implement epigenetic testing in diagnostic laboratories. The book begins with a historical perspective of genetics and epigenetics and describes the work of pioneers who have helped shape these fields. The various mechanisms by which epigenetics can regulate the function of the genome is described. These include DNA methylation, histone modifications, histone variants, nucleosome positioning, cis-regulatory elements, non-coding RNAs and the three-dimensional organisation of chromatin in the nucleus. These are discussed in the context of embryological development, cancer and imprinting disorders, and include examples of epigenetic changes that can be used in diagnosis, prediction of therapeutic response, prognostication or disease monitoring. Finally, for those wishing to implement epigenetic testing in a diagnostic setting, the book includes a case study that illustrates the clinical utility of epigenetic testing.
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| Other form: | Print version: Hesson, Luke B. Clinical Epigenetics. Singapore : Springer, ©2019 9789811389573
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| Standard no.: | 10.1007/978-981-13-8958-0
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