Hidden Bibliographic Details
| Other authors / contributors: | Kimple, Randall J.
|
|---|
| ISBN: | 9780128178690
0128178698
9780128178683
|
|---|
| Notes: | Restoration of wild-type p53 confirmation and function in HNSCC as a novel therapeutic approach
Includes bibliographical references and index.
Description based on online resource; title from digital title page (viewed on November 27, 2019).
|
|---|
| Summary: | Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance. This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites.
|
|---|
| Other form: | Print version: Kimple, Randall J. Improving the Therapeutic Ratio in Head and Neck Cancer San Diego : Elsevier Science & Technology,c2019 9780128178683
|
|---|
