Hidden Bibliographic Details
| Other authors / contributors: | Spies, Maria, editor.
Malkova, Anna, editor.
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| ISBN: | 9780128144305
0128144300
9780128144299
0128144297
0128139803
9780128139806
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| Digital file characteristics: | data file
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| Notes: | Online resource; title from title details screen (ScienceDirect, viewed February 21, 2018).
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| Summary: | Mechanisms of DNA Recombination and Genome Rearrangements: Intersection between Homologous Recombination, DNA Replication and DNA Repair, Volume 601, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Homologous genetic recombination remains the most enigmatic process in DNA metabolism. The molecular machines of recombination preserve the integrity of the genetic material in all organisms and generate genetic diversity in evolution. The same molecular machines that support genetic integrity by orchestrating accurate repair of the most deleterious DNA lesions, however, also promote survival of cancerous cells and emergence of radiation and chemotherapy resistance. This two-volume set offers a comprehensive set of cutting edge methods to study various aspects of homologous recombination and cellular processes that utilize the enzymatic machinery of recombination. The chapters are written by the leading researches and cover a broad range of topics from the basic molecular mechanisms of recombinational proteins and enzymes to emerging cellular techniques and drug discovery efforts.
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| Other form: | Print version: 9780128144299 0128144297
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