Hidden Bibliographic Details
| Other authors / contributors: | Ruzov, Alexey.
Gering, Martin.
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| ISBN: | 9781071608760
1071608762
1071608754
9781071608753
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| Notes: | Includes index.
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| Summary: | This book provides an overview of methods and experimental protocols that are currently used to analyze the presence and abundance of non-canonical DNA nucleotides in different biological systems. Focusing particularly on the newly discovered and less studied DNA modifications that are enzymatically produced and are likely to play specific roles in various biological processes, the volume explores chromatography- and mass spectrometry-based techniques for the detection and quantification of DNA modifications, antibody-based approaches to study their spatial distribution in different cells and tissues, and methods to analyze their genomic distribution with the help of bioinformatics tools that interrogate the corresponding datasets. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
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| Other form: | Print version: DNA modifications. New York, NY : Humana Press, [2021] 1071608754 9781071608753
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| Standard no.: | 10.1007/978-1-0716-0876-0
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