Hidden Bibliographic Details
| ISBN: | 9789811525094
9811525099
9789811525087
9811525080
9789811525100
9811525102
9789811525117
9811525110
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| Digital file characteristics: | text file PDF
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| Notes: | "Doctoral Thesis accepted by The University of Hong Kong, China."
Includes bibliographical references.
Print version record.
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| Summary: | This book presents pioneering findings on the characterization of cellular regulation and function for three recently identified protein posttranslational modifications (PTMs): lysine malonylation (Kmal), glutarylation (Kglu) and crotonylation (Kcr). It addresses three main topics: (i) Detecting Kmal substrates using a chemical reporter, which provides important information regarding the complex cellular networks modulated by Kmal; (ii) Identifying Kglu as a new histone PTM and assessing the direct impact of histone Kglu on chromatin structure and dynamics; and (iii) Revealing Sirt3's value as a regulating enzyme for histone Kcr dynamics and gene transcription, which opens new avenues for examining the physiological significance of histone Kcr. Taken together, these studies provide information critical to understanding how these protein PTMs are associated with various human diseases, and to identifying therapeutic targets for the dysregulation of these novel protein markers in various human diseases.
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| Other form: | Print version: Bao, Xiucong. Study on the Cellular Regulation and Function of Lysine Malonylation, Glutarylation and Crotonylation. Singapore : Springer Singapore Pte. Limited, ©2020 9789811525087
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| Standard no.: | 10.1007/978-981-15-2509-4
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