Circadian pharmacokinetics /

Circadian pharmacokinetics /

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Bibliographic Details
Imprint:	Singapore : Springer, [2020]
Description:	1 online resource (vii, 253 pages) : illustrations (some color)
Language:	English
Subject:	Medicine. Pharmacology. Pharmacy. Pharmacokinetics. Circadian rhythms. Chronopharmacology. Pharmacokinetics. Circadian Rhythm. Chronobiology Phenomena. Chronopharmacology. Circadian rhythms. Pharmacokinetics.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/12608791

Hidden Bibliographic Details
Other authors / contributors:	Wu, Baojian, editor. Lu, Danyi, editor. Dong, Dong, editor.
ISBN:	9789811588075 9811588074 9811588066 9789811588068
Digital file characteristics:	text file PDF
Notes:	Description based upon print version of record. Includes bibliographical references.
Summary:	This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.
Other form:	Print version: Wu, Baojian Circadian Pharmacokinetics Singapore : Springer Singapore Pte. Limited,c2020 9789811588068
Standard no.:	10.1007/978-981-15-8807-5

Table of Contents:

Chapter 1. Introduction to mammalian circadian clock system
Chapter 2. Introduction to pharmacokinetics
Chapter 3. Circadian clock and metabolic diseases
Chapter 4. Circadian clock and CYP metabolism
Chapter 5. Circadian clock and non-CYP phase I metabolism
Chapter 6. Circadian clock and phase II metabolism
Chapter 7. Circadian clock and uptake transporters
Chapter 8. Circadian clock and efflux transporters
Chapter 9. Role of pharmacokinetics in chronotherapeutics
Chapter 10. Role of non-pharmacokinetic factors in chronoefficacy.