MHC class I antigens in malignant cells : immune escape and response to immunotherapy /

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Bibliographic Details
Author / Creator:Aptsiauri, Natalia.
Imprint:New York, NY : Springer, c2013.
Description:1 online resource.
Language:English
Series:SpringerBriefs in cancer research ; 6
SpringerBriefs in cancer research ; 6.
Subject:
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/9850064
Hidden Bibliographic Details
Other authors / contributors:Garcia-Lora, Angel Miguel.
Cabrera, Teresa.
ISBN:9781461465430 (electronic bk.)
1461465435 (electronic bk.)
9781461465423
Notes:Includes bibliographical references.
Summary:Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches. A complete characterization of these molecular defects is important for improvement of the strategies for the selection and follow-up of patients undergoing T-cell based cancer immunotherapy. Precise identification of the mechanism leading to MHC class I defects will help to develo