MHC class I antigens in malignant cells : immune escape and response to immunotherapy /

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Bibliographic Details
Author / Creator:	Aptsiauri, Natalia.
Imprint:	New York, NY : Springer, c2013.
Description:	1 online resource.
Language:	English
Series:	SpringerBriefs in cancer research ; 6 SpringerBriefs in cancer research ; 6.
Subject:	Cancer -- Immunological aspects. Major histocompatibility complex. HLA histocompatibility antigens. Cancer -- Immunological aspects. HLA histocompatibility antigens. Major histocompatibility complex. Neoplasms -- immunology. Major Histocompatibility Complex. Histocompatibility Antigens Class II.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/9850064

Hidden Bibliographic Details
Other authors / contributors:	Garcia-Lora, Angel Miguel. Cabrera, Teresa.
ISBN:	9781461465430 (electronic bk.) 1461465435 (electronic bk.) 9781461465423
Notes:	Includes bibliographical references.
Summary:	Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches. A complete characterization of these molecular defects is important for improvement of the strategies for the selection and follow-up of patients undergoing T-cell based cancer immunotherapy. Precise identification of the mechanism leading to MHC class I defects will help to develo

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